MSDS Name:   Acetic anhydride
Synonym:   Acetic oxide; Acetyl oxide; Ethanoic anhydride; Acetic acid anhydride.
Company:   AboutChem.com

**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****

+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
| 108-24-7 |Acetic anhydride | > 97 | 203-564-8 |
+----------------+--------------------------------------+----------+-----------+
Hazard Symbols: C
Risk Phrases: 10 20/22 34

**** SECTION 3 - HAZARDS IDENTIFICATION ****

EMERGENCY OVERVIEW
Flammable. Harmful by inhalation and if swallowed. Causes
burns.Corrosive.Moisture sensitive.

Potential Health Effects
Eye:
Eye damage may be delayed. Contact with liquid is corrosive to the
eyes and causes severe burns. When substance becomes wet or comes in
contact with moisture of the mucous membranes, it will cause
irritation. May cause chemical conjunctivitis and corneal damage.
Skin:
Contact with skin causes irritation and possible burns, especially
if the skin is wet or moist. Prolonged skin contact may be painless
with reddening of the skin followed be a white appearance of the
skin. Skin burns may be delayed. May cause cyanosis of the
extremities. May cause skin rash (in milder cases), and cold and
clammy skin with cyanosis or pale color.
Ingestion:
May cause severe and permanent damage to the digestive tract. Causes
gastrointestinal tract burns. May cause perforation of the digestive
tract. May be harmful if swallowed. Ingestion of large amounts may
cause CNS depression. May cause systemic effects.
Inhalation:
Harmful if inhaled. Causes severe irritation of upper respiratory
tract with coughing, burns, breathing difficulty, and possible coma.
Causes chemical burns to the respiratory tract. May cause lung
damage. Aspiration may lead to pulmonary edema. Vapors may cause
dizziness or suffocation. May cause systemic effects. May cause
burning sensation in the chest.
Chronic:
Effects may be delayed.

**** SECTION 4 - FIRST AID MEASURES ****

Eyes:
In case of contact, immediately flush eyes with plenty of water for
at least 15 minutes. Get medical aid immediately.
Skin:
In case of contact, immediately flush skin with plenty of water for
at least 15 minutes while removing contaminated clothing and shoes.
Get medical aid immediately. Wash clothing before reuse.
Ingestion:
If swallowed, do NOT induce vomiting. Get medical aid immediately.
If victim is fully conscious, give a cupful of water. Never give
anything by mouth to an unconscious person.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial
respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

**** SECTION 5 - FIRE FIGHTING MEASURES ****

General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. During a
fire, irritating and highly toxic gases may be generated by thermal
decomposition or combustion. Water Reactive. Material will react with
water and may release a flammable and/or toxic gas. Use water spray
to keep fire-exposed containers cool. Wear appropriate protective
clothing to prevent contact with skin and eyes. Wear a self-contained
breathing apparatus (SCBA) to prevent contact with thermal
decomposition products. Containers may explode in the heat of a
fire. Flammable liquid and vapor. May ignite or explode on contact
with steam or moist air.
Extinguishing Media:
Use dry sand or earth to smother fire. If water is the only media
available, use in flooding amounts. DO NOT USE WATER! Do NOT use
straight streams of water. Contact professional fire-fighters
immediately. Cool containers with flooding quantities of water until
well after fire is out.

**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****

General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container. Avoid runoff into storm sewers and
ditches which lead to waterways. Clean up spills immediately,
observing precautions in the Protective Equipment section. Remove all
sources of ignition. Use a spark-proof tool. Provide ventilation. Do
not expose spill to water. Spill may be carefully neutralized with
lime (calcium oxide, CaO). Cover with material such as dry soda ash
or calcium carbonate and place into a closed container for disposal.
A vapor suppressing foam may be used to reduce vapors.

**** SECTION 7 - HANDLING and STORAGE ****

Handling:
Remove contaminated clothing and wash before reuse. Do not allow
water to get into the container because of violent reaction. Ground
and bond containers when transferring material. Use spark-proof tools
and explosion proof equipment. Do not breathe dust, vapor, mist, or
gas. Do not get in eyes, on skin, or on clothing. Empty containers
retain product residue, (liquid and/or vapor), and can be dangerous.
Keep away from heat, sparks and flame. Use with adequate ventilation.
Discard contaminated shoes. Do not pressurize, cut, weld, braze,
solder, drill, grind, or expose empty containers to heat, sparks or
open flames. Keep from contact with moist air and steam.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of
ignition. Do not store in direct sunlight. Keep container closed
when not in use. Keep from contact with oxidizing materials. Store in
a cool, dry, well-ventilated area away from incompatible substances.
Keep away from water. Flammables-area.

**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****

Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower. Use adequate general or
local explosion-proof ventilation to keep airborne levels to
acceptable levels.
Exposure Limits
CAS# 108-24-7:
United Kingdom, WEL - TWA: 0.5 ppm TWA; 2.5 mg/m3 TWA
United Kingdom, WEL - STEL: 2 ppm STEL; 10 mg/m3 STEL
United States OSHA: 5 ppm TWA; 20 mg/m3 TWA
Belgium - TWA: 5 ppm VLE; 21 mg/m3 VLE
France - VLE: 5 ppm VLE; 20 mg/m3 VLE
Germany: 5 ppm TWA; 21 mg/m3 TWA
Japan: 5 ppm Ceiling; 21 mg/m3 Ceiling
Malaysia: 5 ppm TWA; 21 mg/m3 TWA
Spain: 5 ppm VLA-ED; 21 mg/m3 VLA-ED

Personal Protective Equipment

Eyes:
Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.

**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****

Physical State: Liquid
Color: colorless
Odor: strong odor - pungent odor - acetic odor
pH: Not available.
Vapor Pressure: 3.9 mm Hg @68F
Viscosity: Not available.
Boiling Point: 137 deg C
Freezing/Melting Point: Not available.
Autoignition Temperature: 332 deg C ( 629.60 deg F)
Flash Point: 52 deg C ( 125.60 deg F)
Explosion Limits, lower: 2.9%
Explosion Limits, upper: 10.3%
Decomposition Temperature:
Solubility in water: Decomposes.
Specific Gravity/Density: 1.0820g/cm3
Molecular Formula: C4H6O3
Molecular Weight: 102.09

**** SECTION 10 - STABILITY AND REACTIVITY ****

Chemical Stability:
Stable. However, may decompose if exposed to moist air or water.
Substance is readily hydrolyzed. Reacts with water to form
corresponding acid.
Conditions to Avoid:
Ignition sources, contact with water, excess heat, exposure to moist
air or water.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong reducing agents, bases, alcohols,
metal powders, moisture.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon
dioxide.
Hazardous Polymerization: Has not been reported.

**** SECTION 11 - TOXICOLOGICAL INFORMATION ****

RTECS#:
CAS# 108-24-7: AK1925000
LD50/LC50:
CAS# 108-24-7: Inhalation, rat: LC50 = 1000 ppm/4H; Oral, rat: LD50
= 1780 mg/kg; Skin, rabbit: LD50 = 4 mL/kg.
Carcinogenicity:
Acetic anhydride -
Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

**** SECTION 12 - ECOLOGICAL INFORMATION ****

Other
For more information, see "HANDBOOK OF ENVIRONMENTAL FATE AND
EXPOSURE DATA."

**** SECTION 13 - DISPOSAL CONSIDERATIONS ****

Dispose of in a manner consistent with federal, state, and local regulations.

**** SECTION 14 - TRANSPORT INFORMATION ****

IATA
Shipping Name: ACETIC ANHYDRIDE
Hazard Class: 8 (3)
UN Number: 1715
Packing Group: II
IMO
Shipping Name: ACETIC ANHYDRIDE
Hazard Class: 8 (3)
UN Number: 1715
Packing Group: II
RID/ADR
Shipping Name: ACETIC ANHYDRIDE
Hazard Class: 8
UN Number: 1715
Packing group: II
USA RQ: CAS# 108-24-7: 5000 lb final RQ; 2270 kg final RQ

**** SECTION 15 - REGULATORY INFORMATION ****

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: C
Risk Phrases:
R 10 Flammable.
R 20/22 Harmful by inhalation and if swallowed.
R 34 Causes burns.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 108-24-7: 1
Canada
CAS# 108-24-7 is listed on Canada's DSL List.
CAS# 108-24-7 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 108-24-7 is listed on the TSCA inventory.

**** SECTION 16 - ADDITIONAL INFORMATION ****

MSDS Creation Date: 10/09/1998 Revision #13 Date: 2/24/2005

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