MSDS Name:   HBTU 0.1M in (HOBT 0.45M in DMF) 1:1, 3-bottle kit, peptide synthesis
Synonym:  
Company:   AboutChem.com

**** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS ****

+----------------+--------------------------------------+----------+-----------+
| CAS# | Chemical Name | % | EINECS# |
|----------------|--------------------------------------|----------|-----------|
|----------------|--------------------------------------|----------|-----------|
| 68-12-2 |Dimethylformamide | | 200-679-5 |
|----------------|--------------------------------------|----------|-----------|
| 2592-95-2 |1-Hydroxybenzotriazole | | 219-989-7 |
|----------------|--------------------------------------|----------|-----------|
| 94790-37-1 |o-Benzotriazol-1-yl-tetramethyluronium| | unlisted |
+----------------+--------------------------------------+----------+-----------+
Text for R-phrases: see Section 16
Hazard Symbols: T F
Risk Phrases: 11 20/21 36 61

**** SECTION 3 - HAZARDS IDENTIFICATION ****

EMERGENCY OVERVIEW
Highly flammable. Harmful by inhalation and in contact with skin.
Irritating to eyes. May cause harm to the unborn child.

Potential Health Effects
Eye:
Causes eye irritation.
Skin:
May cause skin irritation. Harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract.
Inhalation:
Harmful if inhaled. May cause respiratory tract irritation.
Chronic:
Possible risk of harm to the unborn child.

**** SECTION 4 - FIRST AID MEASURES ****

Eyes:
Flush eyes with plenty of water for at least 15 minutes,
occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15
minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not
breathing, give artificial respiration. If breathing is difficult,
give oxygen.
Notes to Physician:

**** SECTION 5 - FIRE FIGHTING MEASURES ****

General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

**** SECTION 6 - ACCIDENTAL RELEASE MEASURES ****

General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth),
then place in suitable container.

**** SECTION 7 - HANDLING and STORAGE ****

Handling:
Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on
skin, or on clothing. Use only in a chemical fume hood.
Storage:
Store in a cool, dry place. Store in a tightly closed container.
Flammables-area.

**** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ****

Engineering Controls:
Facilities storing or utilizing this material should be equipped
with an eyewash facility and a safety shower.
Exposure Limits
CAS# 68-12-2:
United Kingdom, WEL - TWA: 10 ppm TWA; 30 mg/m3 TWA
United Kingdom, WEL - STEL: 20 ppm STEL; 61 mg/m3 STEL
United States OSHA: 10 ppm TWA; 30 mg/m3 TWA
Belgium - TWA: 10 ppm VLE; 30 mg/m3 VLE
France - VME: 10 ppm VME; 30 mg/m3 VME
Germany: 10 ppm TWA; 30 mg/m3 TWA
Germany: Skin absorber
Japan: 10 ppm OEL; 30 mg/m3 OEL
Malaysia: 10 ppm TWA; 30 mg/m3 TWA
Netherlands: 5 ppm MAC; 15 mg/m3 MAC
Russia: 10 mg/m3 TWA
Spain: 10 ppm VLA-ED; 30 mg/m3 VLA-ED
CAS# 2592-95-2:

CAS# 94790-37-1:


Personal Protective Equipment

Eyes:
Not available.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Use a
NIOSH/MSHA or European Standard EN 149 approved
respirator if exposure limits are exceeded or if
irritation or other symptoms are experienced.

**** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES ****

Physical State: Not available.
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula:
Molecular Weight:

**** SECTION 10 - STABILITY AND REACTIVITY ****

Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials, ignition sources.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

**** SECTION 11 - TOXICOLOGICAL INFORMATION ****

RTECS#:
CAS# 68-12-2: LQ2100000
CAS# 2592-95-2: DM1288000
CAS# 94790-37-1 unlisted.
LD50/LC50:
CAS# 68-12-2: Inhalation, mouse: LC50 = 9400 mg/m3/2H; Inhalation,
rat: LC50 = 3421 ppm/1H; Inhalation, rat: LC50 = 3421 ppm/3H;
Inhalation, rat: LC50 = 1948 ppm/4H; Oral, mouse: LD50 = 2900 mg/kg;
Oral, rabbit: LD50 = 5 gm/kg; Oral, rat: LD50 = 2800 mg/kg; Skin,
rabbit: LD50 = 4720 mg/kg; Skin, rat: LD50 = >3.2 gm/kg.
CAS# 2592-95-2: Draize test, rabbit, eye: 100 mg Mild.
CAS# 94790-37-1.
Carcinogenicity:
Dimethylformamide -
Not listed by ACGIH, IARC, or NTP.
1-Hydroxybenzotriazole -
Not listed by ACGIH, IARC, or NTP.
o-Benzotriazol-1-yl-tetramethyluronium hexafluorophosphate -
Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

**** SECTION 12 - ECOLOGICAL INFORMATION ****



**** SECTION 13 - DISPOSAL CONSIDERATIONS ****

Dispose of in a manner consistent with federal, state, and local regulations.

**** SECTION 14 - TRANSPORT INFORMATION ****

IATA
Shipping Name: N,N-DIMETHYLFORMAMIDE
Hazard Class: 3
UN Number: 2265
Packing Group: III
IMO
Shipping Name: N,N-DIMETHYLFORMAMIDE
Hazard Class: 3
UN Number: 2265
Packing Group: III
RID/ADR
No information available.
USA RQ: CAS# 68-12-2: 100 lb final RQ; 45.4 kg final RQ

**** SECTION 15 - REGULATORY INFORMATION ****

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T F
Risk Phrases:
R 61 May cause harm to the unborn child.
R 11 Highly flammable.
R 20/21 Harmful by inhalation and in contact with
skin.
R 36 Irritating to eyes.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 16 Keep away from sources of ignition - No
smoking.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 68-12-2: 1
CAS# 2592-95-2: No information available.
CAS# 94790-37-1: No information available.
Canada
CAS# 68-12-2 is listed on Canada's DSL List.
CAS# 2592-95-2 is listed on Canada's DSL List.
CAS# 68-12-2 is listed on Canada's Ingredient Disclosure List.
CAS# 2592-95-2 is not listed on Canada's Ingredient Disclosure List.
CAS# 94790-37-1 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 68-12-2 is listed on the TSCA inventory.
CAS# 2592-95-2 is listed on the TSCA inventory.
CAS# 94790-37-1 is not listed on the TSCA inventory.
It is for research and development use only.

**** SECTION 16 - ADDITIONAL INFORMATION ****

Text for R-phrases from Section 2
MSDS Creation Date: 1/16/2002 Revision #1 Date: 10/05/2004

The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no way shall the company be
liable for any claims, losses, or damages of any third party or for lost
profits or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if the company has been advised of
the possibility of such damages.
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